Media & Press Updates
From new version releases to exciting news related to fundraising, we want you to stay in the loop when it comes to Esya Labs. Read our updates below to find out what we’ve been up to recently, and if you have any questions at all, don’t hesitate to get in touch. We’re always happy to hear from you.
Could This Blood Test Revolutionise How Dementia and Other Neurodegenerative Diseases Are Diagnosed?
By Serene Oppenheim
Esya Labs is on a mission is to revolutionize the way neurodegenerative diseases such as dementia are currently diagnosed, building precision diagnostics using their breakthrough cell-scanning nanotechnology for early and accurate identification, well before the disease symptoms manifest physically.
Yamuna Krishnan's Goal: Find Drugs for Neurodegenerative Diseases
Esya Labs, is developing DNA nanodevices that track drug responses, screen for new therapies, and more. sensors can detect specific chemical signatures, like ion levels, inside the organelles of cells, especially lysosomes.
A DNA nanomachine that maps spatial and temporal pH changes inside living cells
DNA nanomachines are synthetic assemblies that switch between defined molecular conformations upon stimulation by external triggers. Previously, the performance of DNA devices has been limited to in vitroapplications.
A pH-correctable, DNA-based fluorescent reporter for organellar calcium
It is extremely challenging to quantitate lumenal Ca2+ in acidic Ca2+stores of the cell because all Ca2+ indicators are pH sensitive, and Ca2+transport is coupled to pH in acidic organelles. We have developed a fluorescent DNA-based reporter, CalipHluor, that is targetable to specific organelles
A DNA nanomachine chemically resolves lysosomes in live cells
Lysosomes are multifunctional, subcellular organelles with roles in plasma membrane repair, autophagy, pathogen degradation and nutrient sensing. Dysfunctional lysosomes underlie Alzheimer’s disease, Parkinson’s disease and rare lysosomal storage diseases, but their contributions to these pathophysiologies are unclear. Live imaging has revealed lysosome subpopulations with different physical characteristics including dynamics, morphology or cellular localization.
DNA nanodevices map enzymatic activity in organelles
Cellular reporters of enzyme activity are based on either fluorescent proteins or small molecules. Such reporters provide information corresponding to wherever inside cells the enzyme is maximally active and preclude minor populations present in subcellular compartments. Here we describe a chemical imaging strategy to selectively interrogate minor, subcellular pools of enzymatic activity.
High lumenal chloride in the lysosome is critical for lysosome function
Dysfunctional lysosomes give rise to lysosomal storage disorders as well as common neurodegenerative diseases. Here, we use a DNA-based, fluorescent chloride reporter to measure lysosomal chloride in Caenorhabditis elegans as well as murine and human cell culture models of lysosomal diseases.
Two DNA nanomachines map pH changes
along intersecting endocytic pathways inside
the same cell
Here, we show that two distinct DNA nanomachines can be used simultaneously to map pH gradients along two different but intersecting cellular entry pathways. The two nanomachines, which are molecularly programmed to enter cells via different pathways, can map pH changes within well-defined subcellular environments along both pathways inside the same cell.