Our Assays

Our 360° Perspective Alzheimer's solutions are based on our patented DNA nanoprobes, our own type of cell based assays. Our assays are unique in their ability to profile the parameters of key chemicals within Endosomes (Early, Recycling and Late), Lysosomes , and Golgi.

They are applicable far beyond Alzheimer's Disease only, and can be used to accelerate drug development across a large number of diseases that interact with or affect the endosomal, lysosomal pathways, or the Golgi.

 

Get in touch to discuss how our probes can help you with your work, for example but not limtied to various rare diseases, drug efficacy, or Cancer.

Single-Ion Sensors

  • iSwitch

    DNA based pH Sensor, FRET based, Multiple colours, multiplexing enabled.

    Relevant for Lysosomal storage Disorders, Niemann Pick, Alzheimer's

  • Clensor

    pH-independent, ratiometric Cl sensor , single colour, multiplexing enabled

    Relevant for e.g. Lysosomal storage Disorders and Niemann Pick

  • Rhod-5F N3

    Red shifted Calcium sensor, Click chemistry ready, easy conjugation with antibodies, proteins, and other biomolecules

    Relevant for Alzheimer’s, Kufor Rakeb syndrome, and Virus entry

  • NOckout

    DNA-based ratiometric NO sensitive probes

    Relevant for cancer, autoimmune disease, sepsis and trauma, and vascular disease

  • Voltair

    DNA based sensor for absolute membrane
    potential of cell and organelle membranes

    Relevant for various neurological diseases, hypokalemia or hyperkalemia

 

Dual-Ion Sensors

  • ChloropHore

    DNA based ratiometric combination reporter
    of pH and Cl

    Relevant e.g. for Niemann Pick A/B/C, and as a 
    Drug efficacy assay

  • CalipHluor

    DNA based, ratiometric combination reporter of pH and Ca 2+

    Relevant for e.g. Alzheimer’s Disease, and Kufor Rakeb syndrome

  • HOCl

    pH-independent, DNA based ratiometric
    fluorescent reporter of pH and HOCl

    Relevant e.g. for Multiple Sclerosis and Acute
    coronary syndrome

  • NOckout

    DNA-based ratiometric NO sensitive probes

    Relevant for cancer, autoimmune disease, sepsis and trauma, and vascular disease

  • Voltair

    DNA based sensor for absolute membrane
    potential of cell and organelle membranes

    Relevant for various neurological diseases, hypokalemia or hyperkalemia

 

Enzyme activity sensors

  • Cat ON

    DNA based turn ON sensor for Cathepsin C

    Relevant for e.g. Papillon Lefèvre syndrome

  • TDX ON

    DNA based ratiometric reporter of disulfide
    reduction

    Relevant for e.g. Pathogen infection

 
 

frequently asked questions

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Science Lab