Our Assays

Our 360° Perspective Alzheimer's solutions are based on our patented DNA nanoprobes, our own type of cell based assays. Our assays are unique in their ability to profile the parameters of key chemicals within Endosomes (Early, Recycling and Late), Lysosomes , and Golgi.

They are applicable far beyond Alzheimer's Disease only, and can be used to accelerate drug development across a large number of diseases that interact with or affect the endosomal, lysosomal pathways, or the Golgi.

Get in touch to discuss how our probes can help you with your work, for example but not limtied to various rare diseases, drug efficacy, or Cancer.

Single-Ion Sensors

iSwitch
DNA based pH Sensor, FRET based, Multiple colours, multiplexing enabled.

Relevant for Lysosomal storage Disorders, Niemann Pick, Alzheimer's
Clensor
pH-independent, ratiometric Cl sensor , single colour, multiplexing enabled

Relevant for e.g. Lysosomal storage Disorders and Niemann Pick
Rhod-5F N3
Red shifted Calcium sensor, Click chemistry ready, easy conjugation with antibodies, proteins, and other biomolecules

Relevant for Alzheimer’s, Kufor Rakeb syndrome, and Virus entry
NOckout
DNA-based ratiometric NO sensitive probes

Relevant for cancer, autoimmune disease, sepsis and trauma, and vascular disease
Voltair
DNA based sensor for absolute membrane
potential of cell and organelle membranes

Relevant for various neurological diseases, hypokalemia or hyperkalemia

Dual-Ion Sensors

ChloropHore
DNA based ratiometric combination reporter
of pH and Cl

Relevant e.g. for Niemann Pick A/B/C, and as a
Drug efficacy assay
CalipHluor
DNA based, ratiometric combination reporter of pH and Ca 2+

Relevant for e.g. Alzheimer’s Disease, and Kufor Rakeb syndrome
HOCl
pH-independent, DNA based ratiometric
fluorescent reporter of pH and HOCl

Relevant e.g. for Multiple Sclerosis and Acute
coronary syndrome
NOckout
DNA-based ratiometric NO sensitive probes

Relevant for cancer, autoimmune disease, sepsis and trauma, and vascular disease
Voltair
DNA based sensor for absolute membrane
potential of cell and organelle membranes

Relevant for various neurological diseases, hypokalemia or hyperkalemia

Enzyme activity sensors

Cat ON
DNA based turn ON sensor for Cathepsin C

Relevant for e.g. Papillon Lefèvre syndrome
TDX ON
DNA based ratiometric reporter of disulfide
reduction

Relevant for e.g. Pathogen infection

frequently asked questions

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