Our Assays

Our 360° Perspective Alzheimer's Disease solutions are based on our patented DNA nanoprobes, our own type of cell-based assays. Our assays are unique in their ability to profile the parameters of key chemicals within Endosomes (Early, Recycling, and Late), Lysosomes, and the Golgi.

They are applicable beyond Alzheimer's Disease and can be used to accelerate drug development across a large number of diseases that interact with or affect endosomal/lysosomal pathways or the Golgi.

 

Get in touch to discuss how our probes can help you with your work (eg. various rare diseases, drug efficacy, or cancer).

Single-Ion Sensors

iSwitch

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DNA based pH Sensor, FRET based, Multiple colours, multiplexing enabled.

Relevant for Lysosomal storage Disorders, Niemann Pick, Alzheimer's

Rhod-5F N3

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Red shifted Calcium sensor, Click chemistry ready, easy conjugation with antibodies, proteins, and other biomolecules

Relevant for Alzheimer’s, Kufor Rakeb syndrome, and Virus entry

Voltair

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DNA based sensor for absolute membrane
potential of cell and organelle membranes

Relevant for various neurological diseases, hypokalemia or hyperkalemia

Clensor

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pH-independent, ratiometric Cl sensor , single colour, multiplexing enabled

Relevant for e.g. Lysosomal storage Disorders and Niemann Pick

NOckout

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DNA-based ratiometric NO sensitive probes

Relevant for cancer, autoimmune disease, sepsis and trauma, and vascular disease

 

Dual-Ion Sensors

ChloropHore

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DNA based ratiometric combination reporter
of pH and Cl

Relevant e.g. for Niemann Pick A/B/C, and as a 
Drug efficacy assay

HOCl

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pH-independent, DNA based ratiometric
fluorescent reporter of pH and HOCl

Relevant e.g. for Multiple Sclerosis and Acute
coronary syndrome

Voltair

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DNA based sensor for absolute membrane
potential of cell and organelle membranes

Relevant for various neurological diseases, hypokalemia or hyperkalemia

CalipHluor

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DNA based, ratiometric combination reporter of pH and Ca 2+

Relevant for e.g. Alzheimer’s Disease, and Kufor Rakeb syndrome

NOckout

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DNA-based ratiometric NO sensitive probes

Relevant for cancer, autoimmune disease, sepsis and trauma, and vascular disease

 

Enzyme Activity Sensors

Cat ON

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DNA based turn ON sensor for Cathepsin C

Relevant for e.g. Papillon Lefèvre syndrome

TDX ON

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DNA based ratiometric reporter of disulfide
reduction

Relevant for e.g. Pathogen infection

 
 

Frequently Asked Questions

Get in touch

Science Lab