ChloropHore

six sets of
ChloropHore

ChloropHore

ESYA’s proprietary A DNA-based ratiometric combination reporter of pH and Cl. It can measure two ion simultaneously from same location allowing high spatial resolution of organelles based on their chemical composition. It is relevant to diseases such as Niemann-Pick’s, as well as drug discovery and efficacy assays. This figure (Leung et al., Nat. Nanotechnol., 2018) illustrates ChloropHore-labelled lysosomes in human dermal fibroblast cells of a healthy individual and two Niemann-Pick’s patients.